STEPHEN MAREN | PROFESSOR | CLAUDE H. EVERETT, Jr. '47 CHAIR OF LIBERAL ARTS
Ph.D., University of Southern California (1993)
Area: Behavioral and Cellular Neuroscience
Member: Institute for Neuroscience
- Neural systems for emotion, learning, and memory
- Contextual regulation of memory encoding and retrieval
- Fear and anxiety
Memories for emotional, particularly fearful, events are vivid, visceral, and enduring. Emotional memories enable us to predict and avoid potential threats, as well as respond to immediate danger. But dysfunction in this system can result in anxiety, panic and post-traumatic stress disorder, for example. Anxiety disorders are the among the most prevalent psychiatric illnesses in the world, affecting nearly one-third of the population. Research in my laboratory seeks to understand the brain circuits and cellular mechanisms underlying the encoding, storage, retrieval, and extinction of aversive memories, and how dysfunction in these circuits and processes contributes to anxiety disorders. We focus on the neurobiology of fear conditioning and extinction in rats and mice. The hippocampus, amygdala, and prefrontal cortex, a triad of interconnected brain areas with essential roles in memory and emotion, are critical for these processes. We use both behavioral and systems neuroscience methods to understand the brain mechanisms of fear and anxiety. These approaches include reversible brain lesions, intracranial pharmacology, electrophysiology, and immunohistochemistry.
Dr. Maren is a recipient of the American Psychological Association Distinguished Scientific Award for an Early Career Contribution to Psychology (2001). He is also a Fellow of the American Psychological Association and Association for Psychological Science, Past-President of the Pavlovian Society, and is currently the Editor-in-Chief of Behavioural Brain Research. He has been continuously funded by the National Institutes of Health since 1995 and is a recipient of the 2015 McKnight Memory and Cognitive Disorders award.
- Neural Substrates of Contextual Memory in Fear Extinction (R01MH065961-12A1), National Institute of Mental Health, $1,868,995 (2015-2020)
- McKnight Memory and Cognitive Disorders Award, McKnight Foundation, $300,000 (2015-2018)
Maren, S. and Holmes, A. (2016). Stress and fear extinction. Neuropsychopharmacology, in press. doi: 10.1038/npp.2015.180. [Epub ahead of print]
Goode, T. D., Kim, J. J., and Maren, S. (2015). Reversible inactivation of the bed nucleus of the stria terminalis prevents the reinstatement but not renewal of extinguished fear. eNeuro, 2(3) e0037-15.2015 1–12. doi: 10.1523/ENEURO.0037-15.2015
Fitzgerald, P. J., Giustino, T. F., Seemann, J. R., Maren, S. (2015). Noradrenergic blockade stabilizes prefrontal activity and enables fear extinction under stress.Proceedings of the National Academy of Science USA, Jun 29. pii: 201500682.
Jin, J. and Maren, S. (2015). Fear renewal preferentially activates ventral hippocampal neurons projecting to both amygdala and prefrontal cortex in rats. Scientific Reports, 5:8388. doi: 10.1038/srep08388.
Goode, T. D., Kim, J. J., and Maren, S. (2015). Relapse of extinguished fear after exposure to a dangerous context is mitigated by testing in a safe context. Learning & Memory, 22:170-178.
Maren, S. (2015). Facing our fears. [Review of the book Anxious: Using the Brain to Understand and Treat Fear and Anxiety, by J. LeDoux]. Science, 349:39. doi: 10.1126/science.aab3289.